Tympanic membrane (TM) perforation is a common otological condition that may lead to conductive hearing loss, recurrent infections, and chronic otitis media if inadequately managed. Classical Ayurvedic texts do not describe TM perforation as an independent disease entity; however, it can be interpreted within the spectrum of Agantuja ear disorders with predominant Vata involvement. Objective: To evaluate the clinical utility of an Ayurvedic therapeutic protocol incorporating Nasya and internal Shamana medications in the management of TM perforation. Methods: A 14-day treatment protocol was administered in two sequential cycles comprising Nasya with Anu Taila and Panchendriyavardhan Taila, along with oral formulations including Laxmivilas Rasa, Sukshma Triphala Vati, and Sarivadi Vati. Clinical monitoring included symptoms, otoscopic assessment, and evaluation of TM healing. Results: The intervention resulted in complete closure of the TM perforation, improvement in auditory acuity, and absence of recurrent otorrhea. No adverse events were recorded. Conclusion: The integrative Ayurvedic protocol demonstrated potential benefits in promoting TM healing. Larger controlled trials are required to validate these findings and establish standardized treatment guidelines.

When consumers are considering a product or service, quality is crucial. It is also significant in terms of life-saving goods like medications. To preserve and improve the quality of pharmaceutical products, the Food and Drug Administration implemented good manufacturing practices (GMP). GMP guarantees that goods are consistently manufactured and managed in accordance with quality standards appropriate for their intended use and as mandated by marketing approval. All of the vital facilities, utilities, and manufacturing equipment in the pharmaceutical sectors must be appropriately certified and validated prior to production, which is one of the main GMP criteria. Currently, this approach constitutes the key of the laws that are closely observed by pharmaceutical businesses worldwide. A validation judgement is a necessary in the pharma sector to verify attachment to pharmaceutical cGMP guidelines, and to help companies maintain consistent quality. When validating a computer system or an information technology system, the same principles are used. It’s crucial to maintain quality standards in pharma since non-conformance might have far-reaching effects.

Nanoparticles (NP) have received a lot of interest and study during the past decade. From current understanding in the field of nanotoxicology, it has become obvious that the most NPs, if not all are more toxic than bulk compounds. Concerns have developed as a result of fast progress and development over the probable dangers to human health and the environment linked with usage and application of neurotoxics. One of the most accessible and widely used nanomaterials in the world is silver nanoparticles (SNPs). Quantification and detection of SNPs in biotechnological systems must be undertaken in a variety of models, so that we can establish how human health may be influenced by these genes. This is important because it is difficult to test all nanomaterials and estimate their effects on human health due to the variety of uses they have. As a result, some scientists think that these adverse effects are tolerable. Nanotechnology has several uses, particularly in the biological sciences and medicine. Nanomaterials are utilised to coat or treat or diagnose.

Because of its patient compliance, convenience of administration, and formulation flexibility, the oral route of medication administration is the most preferred method. However, this approach has several drawbacks, such as restricted gastric residence time (GRT) for sustained drug delivery systems and for medications that are absorbed from certain gastrointestinal tract (GIT) regions. Many strategies have been put out to extend the delivery system's gastric retention period in the upper gastrointestinal tract in order to get around these restrictions. By focussing on site-specific drug release in the upper portion of the GIT, the gastroretentive dosage form (GRDF) extends the GRT. By enabling continuous and prolonged drug release and improving the bioavailability of medications with limited therapeutic windows, GRDFs extend dose intervals and boost patient compliance. This article's goal is to gather the different gastroretentive strategies. We have compiled the key variables influencing stomach retention in order to comprehend the different physiological challenges involved in achieving it. The assessment criteria for gastroretentive medication delivery devices are finally discussed. The current study provides a brief overview of the state of many cutting-edge gastroretentive drug delivery technologies that have been developed thus far, such as high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, ultra porous hydrogel, magnetic systems, etc. Furthermore, significant variables influencing gastroretention are examined, along with benefits and, lastly, prospects for the future.

Background: Traumatic tympanic membrane (TM) perforation commonly heals spontaneously within 2–6 weeks. Ayurveda describes ear trauma under Karnagata Abhighata, where Vranaropana and Vata-Pitta Shamana therapies play an essential role in promoting rapid tissue healing. This case highlights unusually fast healing of a TM perforation following Ayurvedic management. Aim:To assess the rapid healing of a traumatic TM perforation using Ayurvedic treatment modalities.Case Presentation: A 38-year-old female presented with acute left ear pain and mild hearing loss following accidental ear trauma with a ear bud. Otoscopic examination revealed a small central TM perforation without discharge. Ayurvedic assessment suggested Karnagata Abhighata with Vata-Pitta predominance.Intervention: The patient was treated with lukewarm Panchendriya wardhan Taila Nasya, and internal medications Aarogyawardini vati ,Lakshmivilas ras, Kamdudha ras,Avipittakar churna for 14 days. Ear-dry precautions were advised. Results: On Day 14, otoscopic evaluation revealed complete closure of the TM perforation, restoration of normal TM landmarks, and resolution of symptoms. Healing occurred significantly faster than typical spontaneous recovery times. Conclusion: This case demonstrates the potential effectiveness of Ayurvedic management—including Nasya, and Shamana medicines—in accelerating the healing of traumatic TM perforations. Ayurvedic interventions aimed at Vranaropana, Shothahara, and Vata-Pitta Shamana may play a vital role in achieving rapid tissue regeneration. Further clinical studies are warranted to validate these findings.